Giorgio Giardina Selected Research

Glycine Hydroxymethyltransferase (Serine Hydroxymethyltransferase)

1/2021	Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments.
11/2020	Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity.
1/2018	The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.
1/2016	A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells.

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Giorgio Giardina Research Topics

Disease

12	Neoplasms (Cancer) 01/2022 - 03/2015
4	Lung Neoplasms (Lung Cancer) 01/2021 - 01/2016
3	Parkinson Disease (Parkinson's Disease) 01/2017 - 12/2011
2	Neoplasm Metastasis (Metastasis) 06/2021 - 11/2020
2	Adenocarcinoma of Lung 01/2021 - 11/2020
2	Prostatic Neoplasms (Prostate Cancer) 10/2019 - 01/2017
2	Persistent Infection 08/2014 - 11/2012
1	Starvation 11/2020
1	Primary hyperoxaluria type 1 12/2019
1	Primary Hyperoxaluria (Oxaluria, Primary) 12/2019
1	Rare Diseases (Rare Disease) 12/2019
1	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 12/2019
1	Infections 10/2019
1	Hypoxia (Hypoxemia) 10/2019
1	Colonic Neoplasms (Colon Cancer) 01/2019
1	Gyrate Atrophy 01/2019
1	Tourette Syndrome (Tourette's Syndrome) 01/2017
1	Cholangiocarcinoma 01/2017
1	Autoimmune Diseases (Autoimmune Disease) 01/2017
1	Aromatic amino acid decarboxylase deficiency 01/2017
1	Inflammation (Inflammations) 08/2012
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2012
1	Schizophrenia (Dementia Praecox) 12/2011
1	Ischemia 08/2009
1	Breast Neoplasms (Breast Cancer) 10/2002

Drug/Important Bio-Agent (IBA)

5	Serine (L-Serine)FDA Link 01/2021 - 03/2015
4	Amino Acids FDA Link 06/2021 - 11/2020
4	Glycine Hydroxymethyltransferase (Serine Hydroxymethyltransferase)IBA 01/2021 - 01/2016
4	CarbonIBA 01/2021 - 01/2016
3	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2021 - 01/2016
3	EnzymesIBA 01/2016 - 12/2011
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 08/2014 - 08/2009
2	Neurotransmitter Agents (Neurotransmitter)IBA 06/2021 - 12/2011
2	RNA (Ribonucleic Acid)IBA 01/2021 - 01/2019
2	Biological ProductsIBA 12/2019 - 01/2017
2	Glucose (Dextrose)FDA LinkGeneric 10/2019 - 01/2017
2	Protein Isoforms (Isoforms)IBA 01/2018 - 01/2016
2	NitritesIBA 08/2012 - 08/2009
2	Dopamine (Intropin)FDA LinkGeneric 01/2012 - 12/2011
2	Dopa DecarboxylaseIBA 01/2012 - 12/2011
2	Serotonin (5 Hydroxytryptamine)IBA 01/2012 - 12/2011
1	Metformin (Glucophage)FDA LinkGeneric 08/2021
1	BiguanidesIBA 08/2021
1	1,5-dihydro-FADIBA 08/2021
1	NAD (NADH)IBA 08/2021
1	Proteins (Proteins, Gene)FDA Link 01/2021
1	Messenger RNA (mRNA)IBA 01/2021
1	Adenosine Monophosphate (AMP)IBA 11/2020
1	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2020
1	Adenylate KinaseIBA 11/2020
1	Adenosine Triphosphate (ATP)IBA 11/2020
1	Phosphotransferases (Kinase)IBA 11/2020
1	Cycloserine (Seromycin)FDA Link 12/2019
1	glyoxylic acid (glyoxylate)IBA 12/2019
1	Calcium OxalateIBA 12/2019
1	Alanine-glyoxylate transaminase (alanine-glyoxylate aminotransferase)IBA 12/2019
1	Adenosine (Adenocard)FDA LinkGeneric 10/2019
1	Toll-Like Receptor 3IBA 10/2019
1	SaltsIBA 01/2019
1	3-mercaptopyruvate sulphurtransferaseIBA 01/2019
1	5-fluoromethylornithineIBA 01/2019
1	Acetylcysteine (Siran)FDA LinkGeneric 01/2019
1	Transaminases (Aminotransferases)IBA 01/2019
1	AntioxidantsIBA 01/2019
1	OrnithineIBA 01/2019
1	Ornithine-Oxo-Acid Transaminase (Ornithine Aminotransferase)IBA 01/2019
1	sulfur-32IBA 01/2019
1	Sulfides (Thioethers)IBA 01/2019
1	SulfurIBA 01/2019
1	Thymidine Monophosphate (TMP)IBA 01/2018
1	Carboxy-LyasesIBA 01/2017
1	UracilIBA 01/2016
1	NitratesIBA 11/2012
1	PyridoxalIBA 01/2012
1	Cisplatin (Platino)FDA LinkGeneric 10/2002
1	lonidamineIBA 10/2002
1	Epirubicin (Ellence)FDA LinkGeneric 10/2002

Therapy/Procedure

1	Ligation 01/2022
1	Therapeutics 08/2012
1	Drug Therapy (Chemotherapy) 10/2002